Zahra, Henita (2025) Hubungan Ketepatan Penyesuaian Dosis Antibiotik Aminoglikosida Dengan Clinical Dutcome Pada Pasien Gagal Ginjal Kronik. Skripsi thesis, Universitas Pakuan.
Full text not available from this repository.Abstract
Chronic Kidney Disease is a condition where there is damage in the structure and function of the kidneys for ≥ 3 months and it’s irreversible. Patients with Chronic Kidney Disease have low immunity so they tend to be more prone to infection. Aminoglycosides are one of the oldest types of antibiotics that can be used to treat various infections and effective against both gram-negative and some gram-positive pathogens. Aminoglycosides are bactericidal and broad-spectrum antibiotics with a lower level of resistance. This study was conducted to evaluate the dose adjustment of aminoglycoside for Chronic Kidney Disease’s patient for infection therapy. This study is an analytical observational study with a restrospective cross-sectional research design at Fatmawati General Hospital included 110 patients who were treated with aminoglycosides based on the inclusion/exclusion criteria. Among 110 cases, the commonly prescribed aminoglycosides were amikacin, gentamicin and streptomycin. The results showed that 55 patients received the right dose of aminoglycosides and 55 patients did not get the right dose of aminoglycosides. The majority of antibiotics used in the category of not the right dose and the category of not the right dose and interval is amikacin. The recommended dosage regimen based on the Giusti Hayton formula for the samples in this study is 62.12 mg/24-48 hours - 635 mg/24 hours (0.01 mg/L - 32.69 mg/L). There are 88 out of 110 patients with improved clinical outcomes and 22 others with clinical outcomes that have not improved. The results of the Chi-Square test showed that there was no relationship between the accuracy of aminoglycoside antibiotic dose adjustment and the clinical outcome of Chronic Kidney Disease patients (p-value = 0.340). The results of multiple logistic regression test showed that there was an effect of hemodialysis on clinical outcome (p-value = 0.041). KEYWORDS: Aminoglycosides, Chronic Kidney Disease, Clinical Outcome, Dose Adjustment, Infection
| Item Type: | Thesis (Skripsi) |
|---|---|
| Subjects: | Fakultas Ilmu Pengetahuan Alam dan Matematika > Farmasi |
| Divisions: | Fakultas Matematika dan Ilmu Pengetahuan Alam > Farmasi |
| Depositing User: | PERPUSTAKAAN FAKULTAS MATEMATIKA DAN ILMU PENGETAHUAN ALAM UNPAK |
| Date Deposited: | 21 Jun 2025 01:59 |
| Last Modified: | 21 Jun 2025 01:59 |
| URI: | http://eprints.unpak.ac.id/id/eprint/9682 |
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