<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Penentuan Kadar KuersetinBunga Talang (clitoria ternate L.) Secara Kromatografi Cair Kinerja Tinggi Berdasarkan Perbedaan Metode Ekstrak"^^ . "Comparison of Maceration and Ultrasound Assisted Extraction\r\nMethod in Determining Quercetin Level Clitoria ternatea L. Flowers\r\nSri Wardatun1*, Akmal Zainul Ahyar2\r\n, Euis Nining3\r\n1,2,3Department of Pharmacy, Universitas Pakuan, Bogor, Indonesia\r\nsri.wardatun@unpak.ac.id\r\nhttps://doi.org/10.33751/jf.vxxix.xxxx\r\nArticle info:\r\nSubmitted : D-M-202X\r\nAccepted : D-M-202X\r\nPublished : D-M-202X\r\nThis work is licensed under a \r\nCreative Commons \r\nAttribution-ShareAlike 4.0 \r\nInternational License\r\nCopyright © 2023\r\nAuthors\r\nPublished by:\r\nUniversitas Pakuan\r\nABSTRACT\r\nButterfly pea flowers (Clitoria ternatea L.) contain the compound quercetin \r\nwhich has been studied extensively. Butterfly pea flowers have shown various \r\npharmacological activities. The extraction method have an impact on the \r\namount of active compound extracted. The aim of this research was to \r\ndetermine the effect of different extraction methods on quercetin levels in C. \r\nternatea L flowers using the High Performance Liquid Chromatography \r\n(HPLC) method. The HPLC system uses an ODS-3 column stationary phase; a \r\nmobile phase mixture of 0.1 % orthophosphoric acid and methanol (36:64); a \r\nflow rate of 1.2 mL/min; and a PDA-UV detector. The extraction methods used \r\nwere maceration, and ultrasound-assisted extraction (UAE) using methanol as a \r\nsolvent. The results showed that the quercetin content of C. ternatea L flower \r\nextract with maceration method results was 1.0669 ± 0.0283 mg/g and with \r\nUAE method was 1.3915 ± 0.1789 mg/g. Statistical test results showed that \r\ndifferences in extraction methods did not have a significant effect on quercetin \r\nlevels. However, the UAE method is considered more efficient in terms of \r\nextraction time, so the UAE method can be used as an alternative for extracting \r\nquercetin from C. ternatea L. flowers.\r\nKeywords: C. ternatea L.; flowers; maceration; UAE; quercetin\r\nINTRODUCTION \r\nClitoria ternatea L. flowers are widely used in traditional medicine. This part has been \r\nused to treat several diseases. The pharmacological activities of C. ternatea L. flowers extract \r\nwere antidiabetic, antioxidant, antimicrobial, anti-inflammatory, anti-arthritic, analgesic, and \r\ncytotoxic (Jeyaraj et al., 2022; Shinde & Khemnar, 2024). C. ternatea L. flowers have striking \r\ncolors, so they are often used as a natural food and drink coloring (Gamage et al., 2021; Rahma \r\net al., 2024). The ethanol extract of C. ternatea L. flowers contain alkaloids, flavonoids, resins, \r\ntannins, polyphenols, saponins, and triterpenoids (Rahma et al., 2024; Jayanti et al., 2021; \r\nSarma et al., 2023; Yee & Than, 2020).\r\nThe widely known active compound in C. ternatea is quercetin. According to Jeyarai et al. \r\n(2020), phytochemical compounds that have been isolated from C. ternatea L. flowers were \r\nquercetin and myricetin glycosides known as anthocyanins. Furthermore, quercetin 3-2G�rhamnosylrutinoside, quercetin 3-neohesperidoside, quercetin 3-rutinoside, quercetin 3-\r\nglucoside, myricetin 3-neohesperidoside, myricetin 3-rutinoside, and myricetin 3-glucoside \r\nwere found in C. ternatea L. flowers (Al-Snafi et al., 2016; Mahajan et al., 2022). Quercetin is \r\none of the natural bioactive products from the flavonol family, which is widely studied because \r\nit has pharmacological activities such as anticancer, anti-inflammatory, anti-obesity, preventing"^^ . "2024-01-19" . . . "Universitas Pakuan"^^ . . . "Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Pakuan"^^ . . . . . . . . . . . . . . . . . . "Sri"^^ . "Wardatun"^^ . "Sri Wardatun"^^ . . "Akmal"^^ . "Zainur Ahyar"^^ . "Akmal Zainur Ahyar"^^ . . "Euis"^^ . "Nining"^^ . "Euis Nining"^^ . . "Universitas Pakuan"^^ . . . "Fakultas Matematika dan Ilmu Pengetahuan Alam"^^ . . . "Program Studi Farmasi"^^ . . . . . . . "Penentuan Kadar KuersetinBunga Talang (clitoria ternate L.) Secara Kromatografi Cair Kinerja Tinggi Berdasarkan Perbedaan Metode Ekstrak (Text)"^^ . . . "3. Draft Skripsi Akmal.pdf"^^ . . "HTML Summary of #7897 \n\nPenentuan Kadar KuersetinBunga Talang (clitoria ternate L.) Secara Kromatografi Cair Kinerja Tinggi Berdasarkan Perbedaan Metode Ekstrak\n\n" . "text/html" . . . "Farmasi"@en . .