<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Hubungan Ketepatan Penyesuaian Dosis Antibiotik Aminoglikosida Dengan Clinical Dutcome Pada Pasien Gagal Ginjal Kronik"^^ . "Chronic Kidney Disease is a condition where there is damage in the structure and function of the kidneys for ≥ 3\r\nmonths and it’s irreversible. Patients with Chronic Kidney Disease have low immunity so they tend to be more\r\nprone to infection. Aminoglycosides are one of the oldest types of antibiotics that can be used to treat various\r\ninfections and effective against both gram-negative and some gram-positive pathogens. Aminoglycosides are\r\nbactericidal and broad-spectrum antibiotics with a lower level of resistance. This study was conducted to evaluate\r\nthe dose adjustment of aminoglycoside for Chronic Kidney Disease’s patient for infection therapy. This study is\r\nan analytical observational study with a restrospective cross-sectional research design at Fatmawati General\r\nHospital included 110 patients who were treated with aminoglycosides based on the inclusion/exclusion criteria.\r\nAmong 110 cases, the commonly prescribed aminoglycosides were amikacin, gentamicin and streptomycin. The\r\nresults showed that 55 patients received the right dose of aminoglycosides and 55 patients did not get the right\r\ndose of aminoglycosides. The majority of antibiotics used in the category of not the right dose and the category\r\nof not the right dose and interval is amikacin. The recommended dosage regimen based on the Giusti Hayton\r\nformula for the samples in this study is 62.12 mg/24-48 hours - 635 mg/24 hours (0.01 mg/L - 32.69 mg/L). There\r\nare 88 out of 110 patients with improved clinical outcomes and 22 others with clinical outcomes that have not\r\nimproved. The results of the Chi-Square test showed that there was no relationship between the accuracy of\r\naminoglycoside antibiotic dose adjustment and the clinical outcome of Chronic Kidney Disease patients (p-value\r\n= 0.340). The results of multiple logistic regression test showed that there was an effect of hemodialysis on clinical\r\noutcome (p-value = 0.041).\r\nKEYWORDS: Aminoglycosides, Chronic Kidney Disease, Clinical Outcome, Dose Adjustment, Infection"^^ . "2025-02-18" . . "Universitas Pakuan"^^ . . . "Fakultas Matematika dan Pengetahuan Alam, Universitas Pakuan"^^ . . . . . . . . . . . "Emy"^^ . "Oktaviana"^^ . "Emy Oktaviana"^^ . . "Henita"^^ . "Zahra"^^ . "Henita Zahra"^^ . . "Dewi"^^ . "Oktaviani"^^ . "Dewi Oktaviani"^^ . . "Universitas Pakuan"^^ . . . "Fakultas Matematika dan Ilmu Pnegetahuan Alam"^^ . . . "Program Studi Farmasi"^^ . . . . . . "HTML Summary of #9682 \n\nHubungan Ketepatan Penyesuaian Dosis Antibiotik Aminoglikosida Dengan Clinical Dutcome Pada Pasien Gagal Ginjal Kronik\n\n" . "text/html" . . . "Farmasi"@en . .