Kusuma Mawah, Ratna Sari (2024) Penentuan Umur Simpan Sediaan Kapsul, Kombinasi Ekstrak Prokoli (|Brassica oleracea) Dan Herba Pegagan (Centtela asiatica) Dengan Variasi Jenis Kemasan. Skripsi thesis, Universitas Pakuan.
Full text not available from this repository.Abstract
Determination of Shelf Life of Capsule Preparations Containing a Combination of Broccoli (Brassica oleracea) Extract and Gotu Kola (Centella asiatica) Herb with Variations in Packaging Types Erni Rustiani , Septia Andini1 , and Ratna Sari Kusumawati2 1Department of Pharmacy, Universitas Pakuan, Bogor, Indonesia, 16143. [email protected] https://doi.org/10.33751/jf.vxxix.xxxx Article info: Submitted : D-M-202X Accepted : D-M-202X Published : D-M-202X This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License Copyright © 2025 Authors Published by: Universitas Pakuan ABSTRACT Shelf life is influenced by the dosage form, the type of packaging used and the durations storage. The capsule dosage form tested contains extracts of broccoli (Brassica oleracea) and gotu kola (Centella asiatica). Broccoli extract contains flavonoids and antioxidants that act as neuroprotective agents, while gotu kola contains asiaticoside compounds known to enhance memory. This study aims to determine the shelf life of capsule preparations combining broccoli and gotu kola extracts packaged in high-density polyethylene (HDPE) plastic bottles and amber glass bottles. The testing method used was the Accelerated Shelf Life Test (ASLT) using the Arrhenius equation model. Testing was conducted under varying temperature and humidity conditions (40°C, 50°C, and 60°C ± 75%) over a period of two months. Observation parameters included physical stability, chemical stability (flavonoid and asiaticoside content), disintegration time, and dissolution rate. The physical observations of the capsule over a two-month period were as follow greenish-brown in color, had a very bitter taste, and a distinct aromatic odor. At week 8, the flavonoid content in capsules stored in HDPE bottles ranged from 1.61 mg/g to 1.98 mg/g, while those in amber glass bottles ranged from 1.36 mg/g to 1.55 mg/g. The asiaticoside content in capsules stored in HDPE bottles ranged from 0.110% to 0.163%, while those in amber glass bottles ranged from 0.136% to 0.148%. In conclusion, the shelf life of the capsules containing broccoli and gotu kola extracts was 1 months, when stored in HDPE plastic bottles, 2 days when stored in amber glass bottles. Keywords: Flavonoids; Asiaticoside; Antidementia; ASLT.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Subjects: | Fakultas Ilmu Pengetahuan Alam dan Matematika > Farmasi |
| Divisions: | Fakultas Matematika dan Ilmu Pengetahuan Alam > Farmasi |
| Depositing User: | PERPUSTAKAAN FAKULTAS MATEMATIKA DAN ILMU PENGETAHUAN ALAM UNPAK |
| Date Deposited: | 15 Jul 2025 02:33 |
| Last Modified: | 15 Jul 2025 02:33 |
| URI: | http://eprints.unpak.ac.id/id/eprint/9775 |
Actions (login required)
 |
View Item |